Molecular responses to hypoxia: ancient pathways, clinical promises
نویسندگان
چکیده
منابع مشابه
Molecular responses to hypoxia: ancient pathways, clinical promises
a staple of life, but like most things, is best consumed in moderation. Too much oxygen, hyperoxia, leads to the excess accumulation of toxic reactive oxygen species (ROS) and has been linked to acute lung injury as well as the retinopathy of prematu-rity. Conversely, ineffective delivery of oxygen to tissues leads to too little oxygen, hypoxia. Generically, hypoxia is a consequence of an imbal...
متن کاملMolecular Responses to Hypoxia-Inducible Factor 1a and Beyond
Cellular response to changes in oxygen tension during normal development or pathologic processes is, in part, regulated by hypoxia-inducible factor (HIF), an oxygen-sensitive transcription factor. HIF activity is primarily controlled through post-translational modifications and stabilization of HIF-1a and HIF-2a proteins and is regulated by a number of cellular pathways involving both oxygen-de...
متن کاملMolecular responses to hypoxia-inducible factor 1α and beyond.
Cellular response to changes in oxygen tension during normal development or pathologic processes is, in part, regulated by hypoxia-inducible factor (HIF), an oxygen-sensitive transcription factor. HIF activity is primarily controlled through post-translational modifications and stabilization of HIF-1α and HIF-2α proteins and is regulated by a number of cellular pathways involving both oxygen-de...
متن کاملClinical iron deficiency disturbs normal human responses to hypoxia
BACKGROUND Iron bioavailability has been identified as a factor that influences cellular hypoxia sensing, putatively via an action on the hypoxia-inducible factor (HIF) pathway. We therefore hypothesized that clinical iron deficiency would disturb integrated human responses to hypoxia. METHODS We performed a prospective, controlled, observational study of the effects of iron status on hypoxic...
متن کاملAdaptational responses to hypoxia.
WITH THE EVOLUTIONARY TRANSITION of life from water to land, adaptation of the organism to changing environmental conditions became critical for survival. One of the most dramatic life-threatening situations is a reduction in oxygen supply to the vital organs. Decreased tissue oxygenation may arise on such different occasions as exposure to low ambient oxygen, i.e., at high altitude, or during ...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2009
ISSN: 1582-1838,1582-4934
DOI: 10.1111/j.1582-4934.2009.00882.x